Memory impairment in schizophrenia: a meta-analysis. Strange feelings: do amygdala abnormalities dysregulate the emotional brain in schizophrenia? Progress in Neurobiology, 77(5), 283–298.Īleman, A., Hijman, R., de Haan, E. The British Journal of Psychiatry: The Journal of Mental Science, 189, 373–378.Īleman, A., & Kahn, R.
Influence of social perception and social knowledge on cognitive and social functioning in early psychosis. The British Journal of Psychiatry: The Journal of Mental Science, 187, 500–509.Īddington, J., Saeedi, H., & Addington, D. Episodic memory-related activation in schizophrenia: meta-analysis. Structural alterations are apparent in both SCZ and BD after first episode of psychosis but present differently in each illness and are more severe in SCZ.Īchim, A. The study concludes that there appear to be important relationships between volume changes in the hippocampus and amygdala and dimensions and severity of symptomatology in psychosis. In keeping with previous work bilateral hippocampus and amygdala volume reductions were also identified in the SCZ patients while in BD patients only evidence of amygdala inflation reached significance. Symptom severity was associated with decreases in hippocampus/amygdala complex volume across groups. This investigation examined the associations between hippocampus and amygdala volumes and symptom dimensions in schizophrenia and bipolar disorder patients after their first episode of psychosis.
However relationships between illness course, neuropathological changes and variations in symptomatology remain unclear. Hippocampus and amygdala changes have been implicated in the pathophysiology and symptomatology of both schizophrenia (SCZ) and bipolar disorder (BD).